#WearingWhite: Cancer immunotherapy

#WearingWhite: Cancer immunotherapy

This Sunday is World Cancer Day. Staff here at the University of Southampton have been wearing white in order to raise awareness of the life-saving research being performed behind the laboratory doors. In fact, today the University of Southampton are celebrating hitting the £25m target for the UK’s first dedicated Centre for Cancer Immunology!

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Why white?!

We have a lot of different cells in our body, in fact there’s thought to be approximately 200 different types of cells, but today I’m talking about our white blood cells. White bloods cells are the superhero cells, their role is to protect us from infection, disease and foreign invaders to keep us healthy. Here in Southampton, these white blood cells are being used in laboratory research to develop new therapies to fight cancer. The research is being applied into the clinic, and results from clinical trials is showing a lot of promise!

Wearing White

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We are the cure

Immunology is a pretty complex field, and so I’m not going to go into the details (you’d be sat here reading for hours trying to get a grip on a lot of different molecules), but basically, researchers have found that our immune system could actually be used to cure cancer. That’s pretty neat right?!

A type of treatment called immunotherapy harnesses the power of the body’s immune system to recognise and destroy cancer cells (see video below). Cancer cells have the ability to switch off or confuse our killer T cells which then enable the cancer cells to grow. Cancer cells are very hard to defeat! Immunotherapy switches these killer T cells back on and so those useful killer T cells become back in action. They are then able to detect the invasive cancer cells (and potentially any hidden cancer cells!) and destroy them, providing long lasting action to protect against cancer growth. There are different types of immunotherapy including the use of monoclonal antibodies, vaccines, cytokines and adoptive cell transfer and you can read more about these here! They’re all about enhancing the ability of the T cells to recognise the cancer cells. Immunotherapy has the potential to provide us with a lifetime immunity to cancer.

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Successes

Cancer is one of the leading causes of death worldwide, but the results from cancer immunology clinical trials suggest great hope for controlling and curing most cancers.

Immunotherapy clinical trial patients in Southampton:

  • As many as half of the patients with difficult and terminal cancers (often just given months to live) are showing dramatic improvements.
  • 20% patients are cancer free.
  • Drugs for advanced and terminal cancers, such as lung, skin (melanoma), blood (lymphoma), head and neck cancers and childhood cancer (neuroblastoma) are showing outstanding results.

“The cure for Cancer? You’re it.”

– University of Southampton

To read the stories of patients, researchers, fundraisers and donors click here and scroll down the page.

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For extra info click the following links: Cancer Research UK & Cancer Research Institute.

If you are interested in taking part in an immunotherapy clinical trial please contact your GP or cancer specialist.

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If you want to learn some more interesting science then check out my previous science blog posts here.

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